Matrix-based Parameterizations of Skeletal Animated Appearance

Alors que le rendu réaliste gagne de l’ampleur dans l’industrie, les techniques à la fois photoréalistes et basées sur la physique, complexes en terme de temps de calcul, requièrent souvent une étape de précalcul hors-ligne. Les applications en temps réel, comme les jeux vidéo et la réalité virtuelle, se basent sur des techniques d’approximation et de précalcul pour atteindre des résultats réalistes. L’objectif de ce mémoire est l’investigation de différentes paramétrisations animées pour concevoir une technique d’approximation de rendu réaliste en temps réel. Notre investigation se concentre sur le rendu d’effets visuels appliqués à des personnages animés par modèle d’armature squelettique. Des paramétrisations combinant des données de mouvement et d’apparence nous permettent l’extraction de paramètres pour le processus en temps réel. Établir une dépendance linéaire entre le mouvement et l’apparence est ainsi au coeur de notre méthode. Nous nous concentrons sur l’occultation ambiante, où la simulation de l’occultation est causée par des objets à proximité bloquant la lumière environnante, jugée uniforme. L’occultation ambiante est une technique indépendante du point de vue, et elle est désormais essentielle pour le réalisme en temps réel. Nous examinons plusieurs paramétrisations qui traitent l’espace du maillage en fonction de l’information d’animation par squelette et/ou du maillage géométrique. Nous sommes capables d’approximer la réalité pour l’occultation ambiante avec une faible erreur. Notre technique pourrait également être étendue à d’autres effets visuels tels le rendu de la peau humaine (diffusion sous-surface), les changements de couleur dépendant du point de vue, les déformations musculaires, la fourrure ou encore les vêtements.While realistic rendering gains more popularity in industry, photorealistic and physically- based techniques often necessitate offline processing due to their computational complexity. Real-time applications, such as video games and virtual reality, rely mostly on approximation and precomputation techniques to achieve realistic results. The objective of this thesis is to investigate different animated parameterizations in order to devise a technique that can approximate realistic rendering results in real time. Our investigation focuses on rendering visual effects applied to skinned skeletonbased characters. Combined parameterizations of motion and appearance data are used to extract parameters that can be used in a real-time approximation. Trying to establish a linear dependency between motion and appearance is the basis of our method. We focus on ambient occlusion, a simulation of shadowing caused by objects that block ambient light. Ambient occlusion is a view-independent technique important for realism. We consider different parameterization techniques that treat the mesh space depending on skeletal animation information and/or mesh geometry. We are able to approximate ground-truth ambient occlusion with low error. Our technique can also be extended to different visual effects, such as rendering human skin (subsurface scattering), changes in color due to the view orientation, deformation of muscles, fur, or clothe

Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice

Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous CRY1 in mammals will affect circadian rhythm and the relation of such a decrease with apoptosis. Here, we discovered a molecule (M47) that destabilizes Cryptochrome 1 (CRY1) both in vitro and in vivo. The M47 selectively enhanced the degradation rate of CRY1 by increasing its ubiquitination and resulted in increasing the circadian period length of U2OS Bmal1-dLuc cells. In addition, subcellular fractionation studies from mice liver indicated that M47 increased degradation of the CRY1 in the nucleus. Furthermore, M47-mediated CRY1 reduction enhanced oxaliplatin-induced apoptosis in Ras-transformed p53 null fibroblast cells. Systemic repetitive administration of M47 increased the median lifespan of p53−/− mice by ~25%. Collectively our data suggest that M47 is a promising molecule to treat forms of cancer depending on the p53 mutation

The efficacy of udenafil in end-stage renal disease patients undergoing hemodialysis

WOS: 000371797700004PubMed: 26727286Introduction Erectile dysfunction (ED) is frequently observed in end-stage renal disease (ESRD) patients on hemodialysis (HD) compared to non-uremic patients. This situation causes severe psychogenic problems in patients and disrupts the quality of life. Different phosphodiesterase type 5 (PDE-5) inhibitors have been used, and efficacies revealed, for the treatment of ED in HD patients; however, there are no studies related to udenafil use or results for HD patients. This study retrospectively evaluated the efficacy and reliability of udenafil for HD patients. Materials and methods the laboratory findings, side effects after treatment, and International Index of Erectile Function (IIEF) scores before and after treatment were compared and evaluated for HD patients who applied to our urology clinic with ED complaints and were treated with udenafil. Results the results showed that in the HD patient group with ED, apart from ED, there were severe rates of other sexual dysfunction. in our patient group, there was a statistically significant improvement in all scores for erectile function (p=0.033), orgasmic function (p<0.001), sexual desire (p<0.001), relationship satisfaction (p<0.001), and general satisfaction (p<0.001) after treatment. the reported side effects were headache in one patient and dyspepsia in one patient. Conclusion We concluded that udenafil is an effective and reliable treatment approach for HD patients; however, our results require support from prospective randomized crossover studies with sildenafil

Solid-Pseudopapillary neoplasm of the pancreas: A clinicopathological review of 20 cases including rare examples

Aims: Solid-pseudopapillary neoplasm (SPN) is an uncommon malignant tumor of the pancreas with a favorable prognosis unlike other pancreatic neoplasms. We investigated the clinicopathological features of 20 patients with SPN in details

The prevalence of microalbuminuria and relevant cardiovascular risk factors in Turkish hypertensive patients.

Objectives: A growing body of data illustrates the importance of microalbuminuria (MAU) as a strong predictor of cardiovascular risk in the hypertensive population. The present study was designed to define the prevalence of MAU and associated cardiovascular risk factors among Turkish hypertensive outpatients. Study design: Representing the Turkish arm of the multinational i-SEARCH study involving 1,750 sites in 26 countries around the world, a total of 1,926 hypertensive patients from different centers were included in this observational and cross-sectional survey study. Patients with reasons for a false-positive MAU test were excluded. The prevalence of MAU was assessed using a dipstick test, and patients were inquired about comorbidities, comedication, and known cardiovascular risk factors. Results: The overall prevalence of MAU was 64.7% and there was no difference between genders. Most of the patients (82.5%) had uncontrolled hypertension, 35.6% had dyslipidemia, and 35.5% had diabetes, predominantly type 2. Almost one-third of the patients (26.4%) had at least one cardiovascular-related comorbidity, with 20.3% having documented coronary artery disease (CAD). Almost all patients (96.8%) had one or more risk factors for cardiovascular disease in addition to hypertension, including family history of myocardial infarction or CAD, diabetes, dyslipidemia, lack of physical exercise, and smoking. A trend towards higher MAU values in the presence of CAD was determined. Conclusion: Microalbuminuria tests should be routinely used as a screening and monitoring tool for the assessment of subsequent cardiovascular morbidity and mortality among hypertensive patients. © 2011 Turkish Society of Cardiology